There are no specific treatments for WNV. A number of treatment strategies have been investigated and several are currently in clinical trials. These strategies include: vaccines, antivirals and antibody products, none have shown specific benefit to date. The National Institutes of Health maintains a registry of federally and privately supported clinical trials conducted in the United States and around the world.

Until an effective WNV treatment is developed, medical care will consist of supportive care directed toward alleviating disease symptoms. Symptoms and care can be organized into three levels of severity: