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Exam & Evaluation (Antiretroviral Drugs for HIV and AIDS)
 
Questions: Please respond to following statements.

1 A healthy person not infected with HIV has approximately how many CD4+T cells per cubic millimeter of blood?
  300
  500
  1000
  2500
2 The enzyme that HIV uses to transcribe DNA from RNA is:
  protease
  reverse transcriptase
  amylase
  integrase
3 More than 1 million Americans are liviing with HIV infection, what percent do not know they are infected?
  7%
  12%
  21%
  50%
4 All of the following are accurate about antiretroviral drugs except:
  they cure HIV infection
  the drug regimens are complex
  the drugs can have serious side effects
  once started, patients must take antiretroviral drugs indefinitely
5 HIV infected patients are diagnosed with AIDS when their CD+4 count falls below:
  200
  400
  500
  700
6 Nucleoside analogue reverse transcriptase inhibitors work by:
  binding to reverse transcriptase
  preventing the virus from fusing with the membrane around healthy cells
  substituting a synthetic nucleoside, causing a DNA chain termination
  interfering with the protease enzyme
7 Protease inhibitors work by:
  binding to reverse transcriptase
  preventing the virus from fusing with the membrane around healthy cells
  substituting a synthetic nucleoside for a naturally occuring one
  interfering with the maturation of the virus
8 Protease inhibitors interfere with maturation of HIV by cutting p55 and p160.
True     False
9 Fusion inhibitors work by:
  binding to reverse transcriptase
  preventing the virus from fusing with the membrane around healthy cells
  inhibiting the replication of reverse transcriptase
  interfering with the protease enzyme
10 Non-nucleoside reverse transcriptase inhibitors work by:
  binding near the active site of reverse transcriptase
  preventing the virus from fusing with the membrane around healthy cells
  introducing a defective nucleoside into the DNA sequence
  interfering with the protease enzyme
11 Which of these drugs is associated with life-threatening hypersensitivity reaction?
  amprenavir (Agenerase ®)
  efavirenz (Sustiva ®)
  abacavir (Ziagen ®)
  ritonavir (Norvir ®)
12 Nausea and fatigue that don’t resolve are important signs of:
  bone marrow suppression
  lactic acidosis
  hypersensitivity
  drug resistance
13 All of the following statements are accurate about HAART except:
  The goal of HAART is to reduce the amount of HIV in the blood to low or undetectable levels.
  HAART is a major factor in reducing AIDS deaths.
  One potent antiretroviral drug is used until side effects become intolerable.
  Combinations of drugs are used to control HIV.
14 Which of the following antiretroviral drugs can cause altered dreams and sleep disturbances?
  efavirenz (Sustiva ®)
  stavudine (Zerit ®)
  ritonavir (Novir ®)
  didanosine (Videx ®)
15 All of the following are potential benefits of starting HIV drug therapy early except:
  preservation of immune function
  possible decrease in the risk of transmitting the virus to others
  limitation of future treatment options
  lower risk of drug resistance with complete viral suppression
16 HIV drug sequencing is based on:
  drug efficacy
  drug tolerability
  the patient’s disease stage
  all of the above
17 Detecting HIV in the blood 48 weeks after starting treatment or detecting HIV after the viral load has been non-detectable is known as:
  clinical failure
  virologic failure
  immunologic failure
18 What level of antiretroviral compliance must patients achieve to get an 80% likelihood of HIV suppression below detectable levels?
  50%
  60%
  85%
  95%
19 The recommended dose of efavirenz for adults and children weighing more than 40 kg (88 lbs) is 600 mg once daily.
True     False
20 The enzyme_____________ integrates HIV DNA into host cell DNA.
21 Dolutegravir belongs to which class of antiretroviral drugs?
  Non-Nucleoside Reverse Transcriptase Inhibitors
  Protease Inhibitors
  Integrase Inhibitors
  Fusion Inhibitors
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