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Exam & Evaluation (Liver Disease)
 
Questions: Please respond to following statements.

1 Which age group suffers the greatest prevalence of liver disease in the U.S.?
  20 -40 years
  30 -50 years
  40 - 60 years
  50 - 70 years
2 An injured liver accumulates proteinaceous debris in:
  Lobules
  Sinusoids
  Hering's canal
  Mallory bodies
3 In the healthy adult, what percentage of cardiac output enters the hepatic sinusoids?
  15%
  25%
  50%
  75%
4 The primary physiologic function of the Kuppfer cell is:
  Metabolism
  Production of prothrombin and fibrinogen
  Vitamin A storage and
  Phagocytosis of damaged RBCs, bacteria, cellular debris, etc.
5 The amount of albumin synthesized daily by the healthy liver is approximately: (Choose one)
  4 grams
  12grams
  36 grams
  72 grams
6 Which cells are responsible for the fibrosis associated with chronic liver inflammation?
  hepatocytes
  Kupffer cells
  macrophages
  stellate cells
  endothelial cells
7 A definitive diagnosis of cirrhosis is obtained through:
  Detection of a Kayser-Fleisher ring on the cornea
  Ultrasound or CT scan
  Liver function tests
  Liver biopsy
8 Conversion of carbohydrates to glycogen for storage in the liver is known as:
  Glyconeogenesis
  Glycogenesis
  Glycogenolysis
  Glyconeolysis
9 Detoxification of substances by the liver is primarily accomplished by:
  Excreting toxins into the bile
  Making toxins more lipid-soluble for excretion
  Making toxins more water-soluble for excretion
  Conjugating toxin to bilirubin
10 Cirrhosis of the liver increases an individual's risk of developing:
  Primary liver cancer
  Esophageal varices
  Hepato-renal syndrome
  All of the above
11 Vaccines are available to prevent: (Best choice)
  Hepatitis A and C
  Hepatitis B and D
  Hepatitis A and B
  Hepatitis B and C
12 Hepatic encephalopathy associated with ALF may be due to swelling of astrocytes as they convert ammonia to the osmotically active amino acid glutamine.
True     False
13 The best way to decrease the risk of HEV infection when traveling in areas where it is endemic: (Select best answer).
  Drinking only bottled, boiled, or properly treated water
  Not eating raw shellfish or raw uncooked fruits and vegetables
  Not swimming in contaminated water.
  All of the above
14 The most common form of blood-borne hepatitis is:
  HAV
  HBV
  HCV
  HDV
15 Which of the following groups should receive HBV vaccine? (Choose one)
  Health care workers
  Sexually active people, esp. with multiple partners
  Sexual contacts of HBV carriers
  All of the above
16 Lliver transplantation in the United States is primarily due to: (Choose one)
  Hepatocellular carcinoma
  HCV
  HBV
  Wilson's disease
17 HAV is the primary cause of chronic hepatitis worldwide
True     False
18 D-penicillamine chelation therapy may be used to treat Wilson disease.
True     False
19 The role of Alpha 1-antitrypsin is to counteract the inflammatory effects of: (Choose one)
  Copper
  Iron
  Neutrophil elastase
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