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Exam & Evaluation (Understanding Coagulation Tests)
 
Questions: Please respond to following statements.

1 Mechanisms that help produce hemostasis are:
  Vascular spasms
  Platelet plug formation
  Clot formation
  All of the above
2 The expression of which of the following factors initiates the extrinsic coagulation pathway?
  Prothrombin
  Tissue thromboplastin
  Calcium
  Fibrin stabilizing factor
3 Which of the following statements is true of the Prothrombin (PT) time?
  PT time is a measurement of the extrinsic coagulation system.
  Prothrombin is a plasma protein produced by the liver.
  The PT time is affected by coumadin.
  All of the above
4 A way of comparing a PT done in laboratory A to one done in Lab B:
  Time in seconds
  Percentage of activity
  International Normalized Ratio (INR)
5 If a PT control is 11 seconds, a therapeutic range should be approximately:
  11 - 15 seconds
  12 - 20 seconds
  16.5 - 22 seconds
  21.5 - 30 seconds
6 Which of the following drugs increase the PT time?
  Cimetidine
  Sulfonamides
  Antibiotics
  All of the above
7 A patient who is taking a nutritional supplement containing Vitamin K may have a decreased:
  ACT
  PTT
  PT
  Thrombin time
8 The two tests that are used to monitor the effectiveness of heparin therapy are:
  The PT and ACT
  The aPTT and ACT
  The platelet count and PT
  aPTT and fibrin split products
9 If the lab control value for an activated PTT (aPTT) is 30 seconds, a therapeutic level would be approximately:
  20-35 seconds
  35-60 seconds
  45-75 seconds
  60-90 seconds
10 Hemophilia A & B are due to defects in the
  Intrinsic pathway
  Extrinsic pathway
  Platelet membrane
  Antibody inhibitors
11 A patient who has a platelet count of 400,000 may have additional tests to assess for:
  Bone marrow suppression
  Malignancy
  AIDS
  Viral infection
12 Which of the following coagulation tests is abnormal in a patient with hemophilia?
  PT
  Platelet count
  aPTT
  fibrinogen
13 Disseminated intravascular coagulation (DIC) is caused by:
  A decrease in platelets
  Widespread tissue injury that triggers coagulation
  An increase in protein S
  Malignancy
14 Patients with bleeding due to platelet defects:
  Have bleeding right after trauma
  Have bleeding primarily in the skin, mucous membranes, nose, GI and GU tracts
  May have either petechiae or ecchymoses
  All of the above
15 The most common hereditary coagulation disorder is:
  Hemophilia A
  Hemophilia B
  Von Willebrand's disease
16 Which of the following bleeding disorders is caused by antibodies that form against platelets?
  Disseminated intravascular coagulation
  Von Willebrand's disease
  Hemophilia A
  Idiopathic thrombocytopenic purpura
17 A patient who has an excessively prolonged PT may be given:
  Vitamin K
  Protamine sulfate
  Cimetidine
  Salicylates
18 The normal range for an aPTT is:
  10-21 seconds
  20-25 seconds
  25-38 seconds
  120-180 seconds
19 Which of the following tests is used most often to measure the therapeutic effectiveness of coumadin?
  PT
  Fibrinogen and clot retraction time
  Platelet count
  PTT
20 A patient is at high risk of spontaneous bleeding when the platelet count falls below:
  100,000
  50,000
  35,000
  20,000
21 A frequent reason for a high platelet count is:
  Advanced or metastatic cancer
  AIDS
  Viral infections
  Heparin therapy
22 Vitamin K deficiencies can be caused by:
  Poor dietary habits
  Gastrointestinal diseases that impaired absorption of Vitamin K
  Broad spectrum antibiotics that decrease gastrointestinal bacteria that produce Vitamin K
  All of the above
23 The primary problem in Von Willebrand's disease that leads to excessive bleeding is:
  Lack of blood vessel constriction
  Platelet adhesion
  Fibrin stabilization
24 According to the article "Activated Clotting Time" (Knies), the naturally occurring anticoagulant, (part of the intrinsic pathway), that combines with heparin for instantaneous binding of coagulation factors, and immediate anticoagulation, is:
  Tissue factor
  ATIII
  Fibrinogen
  None of the above
25 Which of the following diseases is a consumptive coagulopathy?
  Von Willebrand's disease
  DIC
  Hemophilia B
26 D-dimers result from the breakdown of which substance?
  Fibrin
  Fibrinogen
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