Comparison of Cocaine and Methamphetamines

Both cocaine and methamphetamine are psychostimulants that cause an accumulation of synaptic dopamine. Excess dopamine produces CNS stimulation, feelings of pleasure and euphoria. While they have similar behavioral and psychological effects, their mechanisms of action, metabolism and length of effect differ.

Smoked Cocaine
Smoked Methamphetamine
Plant derived product Synthetic
Effect lasts 20-30 minutes Effect lasts up to 24 hrs
Blocks re-uptake of synaptic dopamine. Causes vesicular release of dopamine and reverses the re-uptake mechanism.
50% drug cleared in 1 hr 50% drug cleared in 12 hrs