Uric acid is the end product of purine metabolism. Purines are obtained from both dietary sources and from the breakdown of body proteins. Organ meats such as liver, kidneys, and sweetbreads, sardines, anchovies, lentils, mushrooms, spinach, and asparagus are all rich sources of purines. The kidneys excrete uric acid as a waste product. The kidneys excrete two-thirds of the uric acid produced daily; the remaining one-third is excreted in the stool. The exact level of uric acid that is considered pathological is controversial. In recent years, it has been recognized that the normal ranges of uric acid are quite wide. Because of this wide range, and because uric acid levels show day-to-day and seasonal variations in the same person, several uric acids levels may be ordered over a period of time. Urine uric acid levels may also be used to evaluate gout or determine oversecretion of uric acid.
Reference values: Serum Uric Acid
The normal range for urinary uric acid is between 250 - 750 mg over a 24-hour period. Uric acid levels tend to vary day to day. It is also important to check the laboratory reference values for each work setting.
An elevated blood uric acid level, also known as hyperuricemia, is seen in:
An overproduction of uric acid occurs when there is excessive cell breakdown and catabolism of nucleonic acids such as seen in gout, excessive production and destruction of cells, as may occur in leukemia or during cancer therapy, or problems with uric acid excretion due to renal failure.
Decreased serum uric acid levels are usually associated with an increase in plasma volume such as with SIADH.
A patient receiving intensive cancer therapy with chemotherapy and radiation may have lower than normal uric acid levels.
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