Alkaline Phosphatase

The highest concentrations of alkaline phosphatase (ALP) are in the kidneys, biliary tract, epithelium, bone, intestinal mucosa, and the placenta. Detection of this ALP is important for determining liver and bone disorders.

Because the liver excretes ALP into the bile, this enzyme is significantly elevated in bile duct obstruction or in bile duct disease such as primary biliary cirrhosis or primary sclerosing cholangitis.