Frascati Criteria |
HIV-associated asymptomatic neurocognitive impairment (ANI)
diagnostic criteria (simplified) |
| Cognitive impairment must be attributable to HIV and no other etiology, i.e: |
- Dementia
- Delirium
- Depression
- CNS neoplasm
- CNS infection
- Cerebrovascular disease
- Substance abuse
- etc.
|
| Impairment involves at least two cognitive domains and result in neuropsychological testing performance at least 1 SD below the appropriate mean age/education norm. |
- Information processing speed
- Sensory/motor skills
- Short-term and long-term memory
- Ability to learn new skills and solve problems
- Attention, concentration, and distractibility
- Logical and abstract reasoning functions
- Ability to understand and express language
- Visual-spatial organization Visual-motor coordination
- Planning, synthesizing and organizing abilities
|
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| Mild Cognitive Disorder (MCD) diagnostic criteria (modified for elucidation) |
| Cognitive impairment must be attributable to HIV and no other etiology, i.e: |
- Dementia
- Delirium
- Depression
- CNS neoplasm
- CNS infection
- Cerebrovascular disease
- Substance abuse
- etc.
|
| Impairment involves at least two cognitive domains and result in neuropsychological testing performance at least 1 SD below the appropriate mean age/education norm. |
- Information processing speed
- Sensory/motor skills
- Short-term and long-term memory
- Ability to learn new skills and solve problems
- Attention, concentration, and distractibility
- Logical and abstract reasoning functions
- Ability to understand and express language
- Visual-spatial organization Visual-motor coordination
- Planning, synthesizing and organizing abilities
|
| Patient or caregivers report that cognitive deficit interferes with: |
- Metal acuity, work efficiency, home making or social activity
|
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| HIV-associated dementia (HAD) diagnostic criteria (modified for elucidation) |
| Cognitive impairment must be attributable to HIV and no other etiology, i.e: |
- Delirium
- Depression
- CNS neoplasm
- CNS infection
- Cerebrovascular disease
- Substance abuse
- etc.
|
| Impairment involves at least two cognitive domains and result in neuropsychological testing at least 2 SD below the appropriate mean age/education norm. |
- Information processing speed
- Short-term and long-term memory
- Ability to learn new skills and solve problems
- Attention, concentration, and distractibility
- Logical and abstract reasoning functions
- Ability to understand and express language
- Visual-spatial organization Visual-motor coordination
- Planning, synthesizing and organizing abilities
|
| Cognitive impairment significantly interferes with: |
- work
- home life
- social activities
- ADL's
|
| Cognitive impairment should be validated by neuropsychological testing, i.e.: |
- Mini-mental state examination (MMSE)
- Memorial Sloan-Kettering (MSK) scale
- HIV dementia Scale (HDS)
|