of Cancer Chemotherapy Terms
therapy a short course of high-dose combination drugs given after
radiation or surgery to destroy residual cancer cells.
Biologic response modifiers (BRMs) -
biologic therapies for the treatment of cancer.
Blood brain barrier a special characteristic
of the capillary walls of the brain that prevent potentially harmful substances
from moving from the bloodstream to the brain and cerebrospinal fluid.
Cancer chemotherapy - the use of drugs to
destroy malignant or cancer cells. The terms antineoplastic, and cytotoxic are
interchangeable with the term cancer chemotherapy.
Cell cycle - a series of steps that both
normal cells and abnormal cancer cells go through in order to grow and reproduce
to form new cells.
Cell cycle time - the amount of time required
for a cell to move from one mitosis (cell division) to another mitosis.
Cell kill theory a theory that proposes
that a set percentage of cells are killed with each dose of chemotherapy.
Chemoprotective agents agents designed
to protect against specific toxic effects of chemotherapy.
Combination chemotherapy the use
of two or more cytotoxic drugs proven effective against a specific type of tumor.
Consolidation therapy chemotherapy
continued after induction therapy has produced a remission.
Growth fraction the percentage of
cells actively dividing at a given point in time.
Induction therapy giving a combination
of high-dose drugs to prompt a complete response to therapy.
Maintenance therapy using single
drugs or combinations of drugs at low doses on a long term basis.
Metastasis the spread of cancer cells
from one part of the body to another.
Nadir the lowest point to which blood
cells levels fall after chemotherapy.
Tumor associated antigens substances
on the surface of the tumor cell that are different than normal cells.
Tumor burden the number of cells
present in the tumor.
Vesicant a cytotoxic drug that
can destroy tissues if an intravenous infiltrates.