Non-nucleoside reverse transcriptase inhibitors (NNRTIs):

These drugs bind close to the active site of the reverse transcriptase enzyme. Once an NNRTI is in place, reverse transcriptase is unable to use the viral RNA as a template. When reverse transcriptase is inactivated, viral DNA cannot be created for insertion into the target cell genome.

Approved drugs in this are associated with rash, Stevens-Johnson syndrome and significant drug interactions.

Generic name
Adverse Effects

Fatigue, elevated liver function tests (⬆LFT), rash, rarely erythema multiforme and Stevens-Johnson syndrome, hepatitis


Mental health problems, (⬆LFT), rash.


⬆LFT, severe rash, allergic reactions, peripheral neuropathy


⬆LFT, hepatitis, liver failure, skin rash, and skin reactions


Insomnia, depression, mood changes, ⬆LFT, ⬆serum creatinine.