Drug-drug interactions are more common and potentially more severe with protease inhibitors than with other classes of antiretroviral drugs. Drug-drug interactions can reduce the effectiveness, and in some cases, can cause life-threatening reactions. There are many drugs that can reduce the effectiveness of antiretroviral drugs. Because some HIV drugs interfere with enzymes that normally metabolize drugs, the serum concentration of many other drugs can be increased.
Many individuals in the U.S. take herbal medicines. However, patients may not consider herbal remedies as "medicines" and may not think of telling their health care providers that they are taking them. Commonly used substances such as garlic supplements and St. Johns wort can affect the serum levels of some HIV drugs.
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