Aspirin is one of the most widely used medicinal compounds in the world. It is an ingredient in hundreds medications and is approved for use as an analgesic, antiinflammatory, anticoagulant and antipyretic. Aspirin produces these effects by inhibiting the oxidation of arachadonic acid by cyclooxygenase 1 & 2.
Arachadonic acid is a ubiquitous membrane fatty acid released in response to injury or stress. Without aspirin, arachadonic acid is initially oxidized by cyclooxygenase to prostaglandin G2, subsequent steps produce: Thromboxane A, prostacyclin I2, prostaglandin E2, prostaglandin D2 and prostaglandin F2a.
Like other non-steroidal aniti-inflammatory drugs (NSAIDS), aspirin has a maximum dose ceiling and significant side effects including increased bleeding time and gastric ulceration.
Aspirin can cause gastric irritation and affects platelet function, thus increasing the risk of bleeding. Aspirin has also been linked to the development of Reyes syndrome in children and teens. Reye's syndrome is a life threatening condition that causes acute encephalopathy and fatty infiltration of the liver and other organs in children recovering from viral infection.
Because of this association,
aspirin should not be given to persons under the age of 20 unless ordered by a physician. Since 2003, the U.S. Food
and Drug Administration (FDA) has required that all aspirin products contain
a warning label describing the potential for the development of Reyes