Ten to 40% of persons with Down syndrome have hypothyroidism, and hyperthyroidism is slightly more common than it is in the general population.
Symptoms may be subtle,
and may be confused with features associated with Down syndrome (e.g. lethargy,
cognitive impairments, and skin dryness) or diagnosed as dementia. Nurses working
with individuals who have hypothyroidism can help set up a reminder system to
ensure that thyroid supplements are taken as directed.